Original Contribution Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study
نویسندگان
چکیده
Jelle Vlaanderen*, Lützen Portengen, Joachim Schüz, Ann Olsson, Beate Pesch, Benjamin Kendzia, Isabelle Stücker, Florence Guida, Irene Brüske, Heinz-Erich Wichmann, Dario Consonni, Maria Teresa Landi, Neil Caporaso, Jack Siemiatycki, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Per Gustavsson, Nils Plato, Karl-Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Adonina Tardón, David Zaridze, John K. Field, Andrea ’t Mannetje, Neil Pearce, John McLaughlin, Paul Demers, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Francesco Forastiere, Bas Bueno-de-Mesquita, Susan Peters, Thomas Brüning, Hans Kromhout, Kurt Straif, and Roel Vermeulen
منابع مشابه
Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study.
The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposur...
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